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MS HARDWARE SPECIFICATIONS
API source: High performance ZSpray™ dual-orthogonal - ESI probe.
Ionization modes:Vacuum isolation valve, Tool free access to customer serviceable elements, Plug and play probes, De-clustering cone gas, Software control of gas flows and heating elements
Ion source transfer optics: High efficiency hexapole ion guide
Mass analyzer: Two high resolution quadrupole analyzers (MS1/MS2), plus prefilters to maximize resolution and transmission while preventing contamination of the main analyzers.
Collision cell: T-Wave™ 1 enabled for optimal MS/MS performance at high data acquisition rates Software programmable gas control
Detector: Low noise, off axis, long life photomultiplier detector, Digital dynamic range up to 4 x 106Vacuum system:
Single, split-flow air-cooled vacuum turbomolecular pump evacuatingthe source and analyzer, One rotary backing pump
Acquisition modes: Full scan MS, Product ion scan, Precursor ion scan, Constant neutral loss, Selected Ion Recording (SIR), Multiple Reaction Monitoring (MRM)
Survey scan modes: Full scan MS triggered product ion scan
Mass range: 2 to 2048 m/z
Scan speed: Up to 10,000 Da/s
Examples of achievable acquisition rates: 10 scans per second (m/z 100 to 1000), 20 scans per second (m/z 50 to 500)
Mass stability: Mass drift is <0.1 Da over a 24 hour period
Linearity of response: The linearity of response relative to sample concentration for a specified compound is five orders of magnitude from the limit of detection
Polarity switching time: 20 ms to switch between positive and negative ion modes
MRM acquisition rate: Minimum dwell time of 3 ms per MRM channel
Inter-channel cross talk: The inter-channel cross talk between two MRM transitions, acquired using an MRM dwell time of 10 ms and an inter-channel delay time of 10 ms, will be less than 0.02%.
Number of MRM channels: Up to 16,384 MRM channels (512 functions, 32 channels per function) can be monitored in a single acquisition; up to 1024 MRM channels when operating in GLP/secure mode (32 functions, 32 channels per function).
Mass resolution: Automatically adjusted (IntelliStart) to desired resolution; The valley between the 2034.63 Da and 2035.63 Da peaks is <12% of the average height of the two peaks.
MRM sensitivity (ESI+): A 1 pg on-column injection of reserpine will give a chromatographic signal-to-noise, greater than 2,000:1 (Gradient separation, LC mobile phase flow rate of 0.8 mL/min, MRM transition m/z 609 > 195).
MRM sensitivity (ESI-): A five pg loop injection of chloramphenicol, with a mobile phase flow rate of 200 &mjicro;L/min will give a chromatographic signal-to-noise for the transition 321 >152 m/z greater than 180:1.
See the Waters Specification Sheet
Used System Details
- Waters Acquity TQ LC-MS/MS
- Waters Acquity Binary Solvent Manager
- Waters Acquity Sample Manager
- Waters Acquity Column Manager
- Waters Acquity Bottle Tray
- PC running both MassLynx 4.1 software and OpenLynx with Open Access Login
- New Sumsung Printer
- Edwards E2M28 Roughing Pump
- Installation & warranty (as denoted above)
- Option to include Sample Organiser - please enquire
* PC Provided with MassLynx software installed. Note: we are unable to transfer licences therefore software licence purchase may be required from the manufacturer.